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Search Result

Search Results for " vhl ligand 1 "

20

Compounds

Cat No. Product Name Synonyms Targets
T4207 (S,R,S)-AHPC hydrochloride VHL Ligand 1 hydrochloride,ULM-1,Protein degrader 1 hydrochloride Others , Ligand for E3 Ligase
(S,R,S)-AHPC hydrochloride (Protein degrader 1 hydrochloride) is a building block in the synthesis of proteolysis-targeting chimera technologies (PROTACs).
T13671 (S,R,S)-AHPC-Me hydrochloride VHL ligand 2 hydrochloride,E3 ligase Ligand 1 Others , Ligand for E3 Ligase
(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is a chemical compound utilized in the synthesis of ARV-771, an exceptionally potent BET protein degrader. This compound selectively degrades BET protein in cell...
T17927 (S,R,S)-AHPC TFA VH032-NH2 TFA,VHL ligand 1 TFA Others , Ligand for E3 Ligase
(S,R,S)-AHPC TFA (VHL ligand 1 TFA) (VH032-NH2 TFA) is a VH032-based ligand designed for von Hippel-Lindau (VHL) protein recruitment. This compound can be linked to protein ligands (e.g., BCR-ABL1) using a linker to crea...
T17922 (S,R,S)-AHPC-PEG3-NH2 hydrochloride VHL Ligand-Linker Conjugates 1 hydrochloride,E3 ligase Ligand-Linker Conjugates 5,VH032-PEG3-NH2 hydrochloride,VHL Ligand-Linker Conjugates 1 HCl Others , E3 Ligase Ligand-Linker Conjugate
(S,R,S)-AHPC-PEG3-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 5) is an E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC-based VHL ligand and 3-unit PEG linker.
T8412 (S,R,S)-AHPC VH032-NH2,MDK7526,VHL ligand 1 Others , Ligand for E3 Ligase
(S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC is potential useful for the targeted degradation of the androgen receptor.
T17920 (S,R,S)-AHPC-PEG1-N3 VHL Ligand-Linker Conjugates 9,VH032-PEG1-N3,E3 ligase Ligand-Linker Conjugates 3 Others , Ligand for E3 Ligase
(S,R,S)-AHPC-PEG1-N3 (E3 ligase Ligand-Linker Conjugates 3) is a synthesized E3 ligase ligand-linker conjugate. (S,R,S)-AHPC-PEG1-N3 incorporates the (S,R,S)-AHPC based VHL ligand and 1-unit PEG linker used in PROTAC tec...
T13671L (S,R,S)-AHPC-Me dihydrochloride VHL ligand 2 dihydrochloride,E3 ligase Ligand 1 dihydrochloride,(S,R,S)-AHPC-Me dihydrochloride (1948273-02-6 free base) Others
(S,R,S)-AHPC-Me dihydrochloride, also known as VHL ligand 2 dihydrochloride, is a chemical compound utilized in the synthesis of ARV-771. ARV-771, a BET PROTAC degrader relying on von Hippel-Landau (VHL) E3 ligase, demon...
T17923 (S,R,S)-AHPC-PEG3-NH2 E3 ligase Ligand-Linker Conjugates 5 Free Base,VH032-PEG3-NH2,VHL Ligand-Linker Conjugates 1 Others
(S,R,S)-AHPC-PEG3-NH2 is a synthetic conjugate of an E3 ligase ligand-linker, incorporating the (S,R,S)-AHPC VHL ligand and a 3-unit PEG linker, which are utilized in PROTAC technology.
T17905 (S,R,S)-AHPC-PEG1-OTs VH032-PEG1-OTs,VHL Ligand-Linker Conjugates 2,E3 ligase Ligand-Linker Conjugates 51 Others
(S,R,S)-AHPC-PEG1-OTs is a chemically synthesized conjugate, functioning as an ligase ligand-linker for E3 ligase. It incorporates the VHL ligand derived from (S,R,S)-AHPC and a 1-unit PEG linker. This synthesized compou...
T7752 (S,R,S)-AHPC-Me VHL ligand 2,E3 ligase Ligand 1A Ligand for E3 Ligase
(S,R,S)-AHPC-Me (E3 ligase Ligand 1A) (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me can be used to synthesize ARV-771. ARV-771 is a...
T18675 (S,R,S)-AHPC-PEG2-NH2 dihydrochloride VH032 amide-PEG2-amine,VH032-PEG2-NH2 dihydrochloride,VH032-linker 12 Others , Ligand for E3 Ligase
(S,R,S)-AHPC-PEG2-NH2 dihydrochloride (VH032-linker 12) is a synthesized E3 ligase ligand-linker conjugate incorporating the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker[1].
T18787 TD-165 Others , Ligand for E3 Ligase
TD-165, a PROTAC-based cereblon (CRBN) degrader, consists of a cereblon (CRBN) ligand-binding group, a linker, and a von Hippel-Landau (VHL) binding group[1].
T17877 VH032-cyclopropane-F VHL ligand 3,E3 ligase Ligand 19,Phenolic VH101 Others , Ligand for E3 Ligase
VH032-cyclopropane-F (Phenolic VH101) is a VH032-based VHL ligand. VH032-cyclopropane-F can be connected to the ligand for protein by a linker to form PROTACs. PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4.
T17881 (S,R,S)-AHPC-C10-NH2 VH032-C10-NH2 Others , Ligand for E3 Ligase
(S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2) is a synthesized E3 ligase ligand-linker conjugate, comprising the (S,R,S)-AHPC-based VHL ligand and a linker, designed for BET-targeted PROTAC applications.
T17697 BRD7-IN-1 Epigenetic Reader Domain
BRD7-IN-1, a modified derivative of BI7273 (BRD7/9 inhibitor), forms PROTAC VZ185 through linkage to a VHL ligand, demonstrating potent activity against BRD7/9 with DC50 values of 4.5 and 1.8 nM, respectively [1].
T5437 Gefitinib-based PROTAC 3 EGFR
Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectivel...
T18600 VH032 thiol VHL ligand 6 Others
VH032 thiol (VHL ligand 6) is a VHL ligand that interacts with pan-BET inhibitor JQ1 through a linker to create a PROTAC[1] compound.
T17908 VHL Ligand-Linker Conjugates 15 E3 Ligase Ligand-Linker Conjugates 56 Others
VHL Ligand-Linker Conjugates 15 is a chemical compound that combines a VHL ligand, which targets the E3 ubiquitin ligase, with a PROTAC linker. It is specifically designed for the creation of PROTACs[1].
T36268 VH 032 Linker 3 (hydrate)
VH 032 linker 3 is a derivative of the proteolysis-targeting chimera technology (PROTAC) building block VHL ligand 1 . N/A
T13958 VHL Ligand 8 Others
VHL Ligand 8, a VHL ligand essential for synthesizing ARD-266, acts as a highly potent VHL E3 ligase-based androgen receptor (AR) PROTAC degrader. It efficiently facilitates the degradation of AR protein in AR-positive p...

Compounds

(S,R,S)-AHPC hydrochloride
T4207
Synonym: VHL Ligand 1 hydrochloride,ULM-1,Protein degrader 1 hydrochloride
Target: Others, Ligand for E3 Ligase
(S,R,S)-AHPC-Me hydrochloride
T13671
Synonym: VHL ligand 2 hydrochloride,E3 ligase Ligand 1
Target: Others, Ligand for E3 Ligase
(S,R,S)-AHPC TFA
T17927
Synonym: VH032-NH2 TFA,VHL ligand 1 TFA
Target: Others, Ligand for E3 Ligase
(S,R,S)-AHPC-PEG3-NH2 hydrochloride
T17922
Synonym: VHL Ligand-Linker Conjugates 1 hydrochloride,E3 ligase Ligand-Linker Conjugates 5,VH032-PEG3-NH2 hydrochloride,VHL Ligand-Linker Conjugates 1 HCl
Target: Others, E3 Ligase Ligand-Linker Conjugate
(S,R,S)-AHPC
T8412
Synonym: VH032-NH2,MDK7526,VHL ligand 1
Target: Others, Ligand for E3 Ligase
(S,R,S)-AHPC-PEG1-N3
T17920
Synonym: VHL Ligand-Linker Conjugates 9,VH032-PEG1-N3,E3 ligase Ligand-Linker Conjugates 3
Target: Others, Ligand for E3 Ligase
(S,R,S)-AHPC-Me dihydrochloride
T13671L
Synonym: VHL ligand 2 dihydrochloride,E3 ligase Ligand 1 dihydrochloride,(S,R,S)-AHPC-Me dihydrochloride (1948273-02-6 free base)
Target: Others
(S,R,S)-AHPC-PEG3-NH2
T17923
Synonym: E3 ligase Ligand-Linker Conjugates 5 Free Base,VH032-PEG3-NH2,VHL Ligand-Linker Conjugates 1
Target: Others
(S,R,S)-AHPC-PEG1-OTs
T17905
Synonym: VH032-PEG1-OTs,VHL Ligand-Linker Conjugates 2,E3 ligase Ligand-Linker Conjugates 51
Target: Others
(S,R,S)-AHPC-Me
T7752
Synonym: VHL ligand 2,E3 ligase Ligand 1A
Target: Ligand for E3 Ligase
(S,R,S)-AHPC-PEG2-NH2 dihydrochloride
T18675
Synonym: VH032 amide-PEG2-amine,VH032-PEG2-NH2 dihydrochloride,VH032-linker 12
Target: Others, Ligand for E3 Ligase
TD-165
T18787
Synonym:
Target: Others, Ligand for E3 Ligase
VH032-cyclopropane-F
T17877
Synonym: VHL ligand 3,E3 ligase Ligand 19,Phenolic VH101
Target: Others, Ligand for E3 Ligase
(S,R,S)-AHPC-C10-NH2
T17881
Synonym: VH032-C10-NH2
Target: Others, Ligand for E3 Ligase
BRD7-IN-1
T17697
Synonym:
Target: Epigenetic Reader Domain
Gefitinib-based PROTAC 3
T5437
Synonym:
Target: EGFR
VH032 thiol
T18600
Synonym: VHL ligand 6
Target: Others
VHL Ligand-Linker Conjugates 15
T17908
Synonym: E3 Ligase Ligand-Linker Conjugates 56
Target: Others
VH 032 Linker 3 (hydrate)
T36268
Synonym:
Target:
VHL Ligand 8
T13958
Synonym:
Target: Others
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